Japanese Journal of Clinical Oncology Advance Access published online on December 6, 2005
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyi198
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1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
* To whom correspondence should be addressed. Background: Paclitaxel has shown promising activity in gastric cancer and has synergism with cisplatin. This study was performed to evaluate the efficacy and toxicity of low-dose paclitaxel (145 mg/m2) plus cisplatin chemotherapy in metastatic or relapsed gastric cancer. Methods: Chemotherapy-naïve patients with metastatic or relapsed gastric cancer were enrolled. Paclitaxel 145 mg/m2 was administered intravenously over 3 h, followed by cisplatin 60 mg/m2 on Day 1 every 3 weeks in the outpatient setting. Results: Of 39 patients enrolled, 17 (44%) had partial responses. Twelve (31%) had stable disease and eight (21%) progressive disease. Two patients (5%) were not evaluable because of early drop-out. The median time to progression was 4.7 months and the median overall survival was 12.1 months. The most common hematologic toxicity was anemia (41%). Grade 3/4 neutropenia and thrombocytopenia developed in 14 and 3%, respectively. The most common non-hematologic toxicities were peripheral neuropathy (43%) and emesis (43%). Grade 3/4 non-hematologic toxicities included emesis (11%), peripheral neuropathy (3%), diarrhea (3%) and hepatotoxicity (3%). Conclusions: Low-dose paclitaxel and cisplatin chemotherapy was active and well-tolerated in chemotherapy-naïve gastric cancer patients. This regimen seems to have comparable efficacy to previously reported higher-dose paclitaxel plus cisplatin-containing regimens and fewer toxicities.
Received July 27, 2005
Accepted October 10, 2005
Original Article
Phase II Trial of Low-dose Paclitaxel and Cisplatin in Patients with Advanced Gastric Cancer
Keun-Wook Lee 1,
Seock-Ah Im 2 *,
Tak Yun 3,
Eun Kee Song 3,
Im il Na 3,
Hyunchoon Shin 3,
In Sil Choi 4,
Do-Youn Oh 4,
Jee Hyun Kim 1,
Dong-Wan Kim 2,
Tae-You Kim 2,
Jong Seok Lee 1,
Dae Seog Heo 2,
Yung-Jue Bang 2,
and
Noe Kyeong Kim 2
2 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
3 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
4 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Seoul Municipal Boramae Hospital, Seoul, Republic of Korea
Seock-Ah Im, E-mail: moisa{at}snu.ac.kr
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