Skip Navigation



Japanese Journal of Clinical Oncology Advance Access published online on January 17, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyi217
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
36/1/12    most recent
hyi217v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Ikeda, J.
Right arrow Articles by Ichinose, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ikeda, J.
Right arrow Articles by Ichinose, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 Foundation for Promotion of Cancer Research
Received July 21, 2005
Accepted December 1, 2005

Original Article

Phase I Study of Amrubicin Hydrochloride and Cisplatin in Patients Previously Treated for Advanced Non-small Cell Lung Cancer

Jiro Ikeda 1, Riichiroh Maruyama 1, Tatsuro Okamoto 1, Fumihiro Shoji 1, Hiroshi Wataya 1, and Yukito Ichinose 1 *

1 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan

* To whom correspondence should be addressed.
Yukito Ichinose, E-mail: yichinos{at}nk-cc.go.jp


  Abstract

Objective: A single-center phase I trial was designed to determine both the dose-limiting toxicities and the maximum tolerated dose (MTD) for amrubicin hydrochloride in combination therapy with cisplatin for advanced non-small cell lung cancer (NSCLC) patients with prior chemotherapy.

Methods: Eligible patients received amrubicin and cisplatin on days 1 through 3 every 3 or 4 weeks. Cisplatin was administered at a fixed dosage of 20 mg/m2 while the administered dose of amrubicin was started at 20 mg/m2. Each group comprised 3 or 6 patients. When dose limiting toxicities were noted in three or more of six patients at a particular level, that level was estimated to be the MTD.

Results: Fifteen patients were enrolled in this study, including 5 males and 10 females, with a median age of 57. The dose limiting toxicities included grade 4 neutropenia which lasted 4 or more days and febrile neutropenia. The non-hematologic toxicities were well managed and rarely severe. The MTD of amrubicin in this combination regimen was estimated to be 30 mg/m2. A partial response was observed in 4 of 15 patients (27%).

Conclusions: The recommended dose was thus determined to be 25 mg/m2 amrubicin with 20 mg/m2 cisplatin for 3 consecutive days. A phase II study is currently underway.

Keywords: amrubicin hydrochloride; cisplatin; non-small cell lung cancer; phase I study; prior chemotherapy.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.