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Japanese Journal of Clinical Oncology Advance Access published online on January 17, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyi225
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© 2006 Foundation for Promotion of Cancer Research

Cancer Genetics Report

Association of the PIG3 Promoter Polymorphism with Invasive Bladder Cancer in a Japanese Population

Masaaki Ito 1, Hiroyuki Nishiyama 1, Jun Watanabe 1, Hiroaki Kawanishi 1, Takeshi Takahashi 1, Toshiyuki Kamoto 1, Tomonori Habuchi 2, and Osamu Ogawa 1 *

1 Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
2 Department of Urology, Akita University of Medicine, Akita, Japan

* To whom correspondence should be addressed.
Osamu Ogawa, E-mail: ogawao{at}kuhp.kyoto-u.ac.jp


  Abstract

PIG3 (p53-induced gene 3) is one of the targets of TP53 and is involved in apoptosis. The promoter of PIG3 contains a variable number of tandem repeats (VNTRs) of pentanucleotides (TGYCC)n (Y = C or T) and the number of VNTRs was reported to be correlated with the activation by TP53. In this study, the clinical significance of the PIG3 promoter VNTRs was analyzed in the bladder cancer patients using the genome DNAs from 338 controls and 273 bladder cancer patients. There was no significant difference in the allele frequency of the PIG3 promoter VNTRs between them. However, the presence of 14 or less repeats allele was associated with higher cancer grade (P = 0.038) and higher stage in relative risk (adjusted odds ratio = 2.31, 95% confidence interval = 1.05-5.90). These data suggested that the PIG3 promoter VNTRs was associated with generation of invasive bladder cancer.

Keywords: PIG3; bladder cancer; VNTRs.
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