Japanese Journal of Clinical Oncology Advance Access published online on May 12, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl008
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1 Department of Radiology, Tokyo Medical Center, National Hospital Organization, Tokyo, Japan
* To whom correspondence should be addressed. Objective: To analyze predictive factors of acute urinary retention requiring catheterization after 125I prostate brachytherapy. Methods: A group of 227 consecutive patients with localized prostate cancer were treated with 125I prostate brachytherapy between September 2003 and December 2004. The clinical, treatment-related and dosimetric factors were evaluated for the need for catheterization owing to urinary retention. Results: Twelve patients (5.3%) required catheterization. The median time to onset was 2 days after implantation (range 1-7 days). Univariate analysis demonstrated that pre-implant ultrasound prostate volume, number of seeds, number of needles and neoadjuvant hormonal manipulation were predictive for catheterization. In multivariate analysis, the number of needles and neoadjuvant hormonal manipulation were significant independent predictive factors for catheterization (P = 0.002 and 0.025, respectively). The risk of catheterization in the cluster in which the number of needles was >24 was 4.07 times as high as that in the cluster in which the number of needles was Conclusion: Our data suggest that the number of needles and hormonal manipulation might be the strongest predictors for catheterization.
Received November 28, 2005
Accepted February 3, 2006
Original Article
Predictive Factors of Acute Urinary Retention Requiring Catheterization Following 125I Prostate Brachytherapy
Toshio Ohashi 1 *,
Atsunori Yorozu 1,
Kazuhito Toya 1,
Shiro Saito 2,
and
Tetsuo Momma 2
2 Department of Urology, Tokyo Medical Center, National Hospital Organization, Tokyo, Japan
Toshio Ohashi, E-mail: tohashi{at}ntmc.hosp.go.jp
Abstract 
24 [11.3% versus 3.0%, P = 0.020; 95% confidence interval (CI) 1.24-13.36], and the risk in the hormonally manipulated patients was 7.05 times as high as that in the hormone-naïve patients (7.7% versus 1.2%, P = 0.034; 95% CI 0.89-55.64).
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