Japanese Journal of Clinical Oncology Advance Access published online on May 11, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl017
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1 Department of Pathology, Wuhan University Medical School, Wuhan City, Hubei Province, People's Republic of China; Department of Respiratory Medicine, Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, People's Republic of China
* To whom correspondence should be addressed. Background: Inconsistency in the prevalence infection by human papillomavirus (hpv) in lung cancer patients were found between different countries with racial and geographic variations. Our previous reports have indicated that a high-risk hpv 16/18 DNA was frequently detected in Chinese lung cancer patients living in Taichung, Taiwan (Cheng et al. Cancer Res. 2001;61:2799-803). Thus, we conducted this study to verify whether there was a similar hpv 16/18 infection prevalence in lung cancer patients from Wuhan, China. Methods: To reduce the false positive hpv detection, the paraffin sections of 73 lung tumors and 34 non-cancer controls from Wuhan, China were collected for detection of the presence of hpv 16/18 DNA by in situ hybridization (ISH). Results: Our results showed that the rates of hpv 16 and/or 18 infections in patients with lung tumors were significantly higher than in 34 non-cancer control subjects (26.0 versus 2.8% for hpv 16, P = 0.030; 23.3 versus 5.7% for hpv 18, P = 0.031; 27.7 versus 5.9% for hpv 16 or 18, P = 0.003) with a similar infection frequency of hpv 16 and 18 types in lung tumors. This result indicated that hpv 16/18 infection may be associated with lung cancer development in Chinese patients from Wuhan, China. Further statistical analyses revealed that hpv 16 or 18 infection was not correlated with any clinico-pathological parameter studied, including age, gender, smoking status, tumor type, tumor stage and tumor grades. Interestingly, smoking and male patients had a higher prevalence of hpv 16, although not reaching a statistical significance, compared with non-smoking and female patients, respectively (33.3% for smokers versus 20.0% non-smokers; 33.3% for male versus 17.6% for female). As compared with the hpv 16/18 infection in Taiwan, Chinese patients with lung cancer from Wuhan had a different hpv 16/18 infection prevalence. Conclusion: Difference in hpv 16/18 infection in lung cancer patients from Wuhan, China and Taichung, Taiwan suggests that hpv 16/18 might play a different role in lung cancer development among Chinese living in different areas.
Received December 6, 2005
Accepted February 8, 2006
Original Article
Different Human Papillomavirus 16/18 Infection in Chinese Non-Small Cell Lung Cancer Patients Living in Wuhan, China
Yang Fei 1,
Jiong Yang 2,
Wei-Chung Hsieh 3,
Jeng-Yuan Wu 4,
Tzu-Chin Wu 5,
Yih-Gang Goan 6,
Huei Lee 7,
and
Ya-Wen Cheng 8 *
2 Department of Respiratory Medicine, Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, People's Republic of China
3 Da Chien General Hospital, Miaoli, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
4 Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan; Department of Surgery, Armed Force Taichung General Hospital, Taichung, Taiwan
5 Department of Pulmonary and Critical Care, Chung Shan Medical University, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
6 Department of Surgery, Kaohsiung Veterans General Hospital, Taiwan; Department of Surgery, National Yang-Ming University, Taipei, Taiwan; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC
7 Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan
8 Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
Ya-Wen Cheng, E-mail: yawen{at}csmu.edu.tw
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