Japanese Journal of Clinical Oncology Advance Access published online on May 30, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl024
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1 Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
* To whom correspondence should be addressed. Background: Cyclooxygenase-2 (COX-2) contributes to invasiveness of cancer through activation of several matrix metalloproteinases (MMPs). Matrix metalloproteinase-2 (MMP-2) is a proteolytic enzyme that degrades the extracellular matrix, and has been linked to invasion and metastasis. This study aims to assess the correlation of the COX-2 expression and the MMP-2 expression in patients with non-small cell lung cancer (NSCLC). Methods: We analyzed the protein expressions of COX-2 and MMP-2 by immunohistochemical staining on the tissue array specimens from 204 patients with completely resected NSCLC. A <10% immunostaining of the cancer cells was considered negative, while >10% was considered positive. Results: The COX-2 expression was positive in 68.1% and that of the MMP-2 was positive in 45.6%. The positive expression rate of MMP-2 (52.5%) in the positive COX-2 group was higher than that in the negative COX-2 group (30.8%, P = 0.004). Furthermore, the MMP-2 expression was associated with lymph node involvement, the tumor stage and the histological type. The patients with a positive MMP-2 expression showed a reduced survival (P = 0.048). Conclusions: The COX-2 expression is associated with the MMP-2 expression in NSCLC patients: the latter may also be associated with tumor progression and reduced survival in NSCLC patients.
Received October 12, 2005
Accepted February 8, 2006
Original Article
Association between Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expression in Non-Small Cell Lung Cancer
Jae Ho Byun 1,
Myung Ah Lee 1 *,
Sang Young Roh 1,
Byoung Yong Shim 1,
Sook Hee Hong 1,
Yoon Ho Ko 1,
Su Jin Ko 1,
In Sook Woo 1,
Jin Hyoung Kang 1,
Young Seon Hong 1,
Kyung Shik Lee 1,
Ah Won Lee 2,
Gyeong Sin Park 2,
and
Kyo Yeong Lee 2
2 Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Myung Ah Lee, E-mail: angelamd{at}catholic.ac.kr
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