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Japanese Journal of Clinical Oncology Advance Access published online on May 30, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl030
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© 2006 Foundation for Promotion of Cancer Research
Received December 24, 2005
Accepted February 13, 2006

Article

Monotherapy with Carbon Ion Radiation for Localized Prostate Cancer

Jun Shimazaki 1 *, Koichiro Akakura 1, Hiroyoshi Suzuki 1, Tomohiko Ichikawa 1, Hiroshi Tsuji 2, Hitoshi Ishikawa 2, Masaoki Harada 3, and Hirohiko Tsujii 2

1 Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan
2 Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
3 Department of Surgical Pathology, Kanagawa Cancer Center, Yokohama, Japan

* To whom correspondence should be addressed.
Jun Shimazaki, E-mail: shimajun{at}opal.famille.ne.jp


  Abstract

Background: Radiation treatment for localized prostate cancer has become a prominent choice of monotherapy, and carbon ion beam is a powerful means for this purpose.

Methods: In total, 37 patients with localized prostate cancer were treated by monotherapy with carbon ion radiation and the outcome, more than 4 years later, was followed.

Results: PSA relapse-free survival was overall 85%, 5 years after radiation, and 96% in low-risk patients. Local control was mostly achieved, and no cancer-specific death was obtained. Except in cases of relapse, 1.0 ng/ml or less of PSA was shown in 78%, 3 years after radiation. Half of biopsy specimens out of 12 cases revealed non-viable or no cancer cells after a rather short time from treatment.

Conclusion: Monotherapy with carbon ion radiation may be an excellent treatment for localized prostate cancer with low risk.

Keywords: prostate cancer; localized stage; radiotherapy; carbon ion radiation.
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