Japanese Journal of Clinical Oncology Advance Access published online on June 9, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl038
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1 Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan; Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
* To whom correspondence should be addressed. Background: While Snail is a zinc-finger transcription factor that triggers the epithelial- mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor Methods: We analyzed Snail mRNA expression levels in 86 node-negative invasive ductal carcinomas by real-time quantitative RT-PCR and studied whether Snail mRNA expression correlates with clinicopathological factors. Results: No correlation was found between Snail mRNA expression and ER Conclusion: Our data show that low expression of Snail mRNA is a good prognostic factor in node-negative invasive ductal carcinomas. Snail expression is suggested to be involved in distant metastasis in node-negative invasive ductal carcinomas.
Received September 4, 2005
Accepted March 22, 2006
Original Article
Low Expression of the Snail Gene is a Good Prognostic Factor in Node-Negative Invasive Ductal Carcinomas
Tatsuya Toyama 1 *,
Zhenhuan Zhang 2,
Hirotaka Iwase 2,
Hiroko Yamashita 2,
Yoshiaki Ando 2,
Maho Hamaguchi 2,
Mitsuhiro Mizutani 3,
Naoto Kondo 3,
Takashi Fujita 3,
Yoshitaka Fujii 2,
and
Hiroji Iwata 3
2 Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
3 Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
Tatsuya Toyama, E-mail: ncu{at}umin.ac.jp
Abstract 
(ER) and to be involved in the transcriptional repression of the aromatase gene. The aim of the present study was to examine the role of Snail expression in node-negative invasive ductal carcinomas. protein expression levels. However, we observed that none of the 34 patients showing low Snail mRNA expression developed distant metastasis while 6 of 52 (12%) showing high expression of Snail mRNA did. The level of Snail mRNA expression was not found to be significantly correlated with clinicopathological factors. No inverse correlation was found between the Snail and aromatase mRNA expression levels in our series.
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