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Japanese Journal of Clinical Oncology Advance Access published online on July 14, 2006

Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl059
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© 2006 Foundation for Promotion of Cancer Research
Received April 4, 2006
Accepted May 1, 2006

Case Report

Distant Metastasis of Prostate Cancer: Early Detection of Recurrent Tumor with Dual-Phase Carbon-11 Choline Positron Emission Tomography/Computed Tomography in Two Cases

Tetsuo Maeda 1, Ukihide Tateishi 1 *, Motokiyo Komiyama 2, Hiroyuki Fujimoto 2, Shun-Ichi Watanabe 3, Takashi Terauchi 4, Noriyuki Moriyama 4, Yasuaki Arai 1, Kazuro Sugimura 5, and Tadao Kakizoe 2

1 Division of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
2 Division of Urology, National Cancer Center Hospital, Tokyo, Japan
3 Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
4 Division of Cancer Screening, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
5 Department of Diagnostic Radiology, Kobe University Graduate School of Medicine, Kobe, Japan

* To whom correspondence should be addressed.
Ukihide Tateishi, E-mail: utateish{at}ncc.go.jp


   Abstract

Several types of recurrence may be detected by radiologic assessment after treatment in patients with prostate cancer. However, early detection of distant metastasis using positron emission tomography has so far never been published. We report two patients who underwent hormone therapy or surgical resection for prostate cancer. They developed distant metastases which were detected on whole body [C-11] choline positron emission tomography/computed tomography with significant elevation of serum PSA level. In one patient, recurrent tumor of the supraclavicular node (6 mm) diminished in size after subsequent hormone therapy. Surgical resection of recurrent tumor of the lung (12 mm) was performed in the other patient, the pathology of which confirmed the metastatic adenocarcinoma derived from the prostate. The recurrent tumor can be correctly detected by dual-phase whole body [C-11] choline positron emission tomography/computed tomography.

Keywords: prostate cancer; carbon-11 choline; positron emission tomography; computed tomography.
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T. Terauchi, U. Tateishi, T. Maeda, D. Kanou, H. Daisaki, Y. Moriya, N. Moriyama, and T. Kakizoe
A Case of Colon Cancer Detected by Carbon-11 Choline Positron Emission Tomography/Computed Tomography: An Initial Report
Jpn. J. Clin. Oncol., October 1, 2007; 37(10): 797 - 800.
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