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Japanese Journal of Clinical Oncology Advance Access published online on July 22, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl063
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© 2006 Foundation for Promotion of Cancer Research
Received April 3, 2006
Accepted May 21, 2006

Original Article

High Levels of Thymidine Phosphorylase as an Independent Prognostic Factor in Renal Cell Carcinoma

Tatsuya Takayama 1 *, Soichi Mugiya 1, Takayuki Sugiyama 1, Takahiro Aoki 1, Hiroshi Furuse 1, Hongming Liu 1, Yasuhiro Hirano 2, Fumitake Kai 3, Tomomi Ushiyama 1, and Seiichiro Ozono 1

1 Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
2 Fujieda Municipal General Hospital, Fujieda, Shizuoka, Japan
3 Haibara General Hospital, Makinohara, Shizuoka, Japan

* To whom correspondence should be addressed.
Tatsuya Takayama, E-mail: takayama{at}hama-med.ac.jp


  Abstract

Background: We investigated whether thymidine phosphorylase (TP) protein level in renal cell carcinoma (RCC) correlates with clinicopathological characteristics and clinical outcomes.

Methods: TP protein level was measured in 116 RCC specimens and in 90 non-neoplastic kidney tissues using a sandwich-type enzyme-linked immunosolvent assay.

Results: The median TP protein level in RCC tissues was 9.76-fold (range, 3.2-933.9) higher than those in non-neoplastic kidney tissues (P < 0.0001). TP protein level was correlated with T classification, histological grade and mode of infiltration. TP as a prognostic variable was studied using a logistic regression model. TP at higher levels (128 U/mg protein or greater) would play a role as an independent prognostic factor (odds ratio, 13.73; 95% confidence interval, 2.09-90.41; P = 0.0064).

Conclusion: TP at high levels can be regarded as an unfavorable independent prognostic factor. These results may pave a way for a novel approach to effective treatment of RCC.

Keywords: renal cell carcinoma; thymidine phosphorylase; prognostic factor.
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