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Japanese Journal of Clinical Oncology Advance Access published online on August 14, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl077
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© 2006 Foundation for Promotion of Cancer Research
Received February 15, 2006
Accepted June 14, 2006

Original Article

Double Cancer of Gall Bladder and Bile Duct not Associated with Anomalous Junction of the Pancreaticobiliary Duct System

Hiiroshige Hori 1, Tetsuo Ajiki 1 *, Tsunenori Fujita 1, Taro Okazaki 1, Yasuyuki Suzuki 1, Yoshikazu Kuroda 1, and Takahiro Fujimori 2

1 Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Kobe, Japan
2 Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga-gun, Tochigi, Japan

* To whom correspondence should be addressed.
Tetsuo Ajiki, E-mail: ajiki{at}med.kobe-u.ac.jp


  Abstract

Background: Simultaneous double cancers of the biliary tract are rare. Most of them are thought to be associated with pancreaticobiliary maljunction (PBM); however, the characteristics of tumours without PBM are still unclear.

Methods: Histology, immunoreactivity with carcinoembryonic antigen, carbohydrate antigen 19-9 and p53 and mutations in the K-ras gene were examined in tumours resected from cases of simultaneous double cancers of the biliary tract.

Results: Four cases of simultaneous double cancers of the biliary tract were identified among 108 patients with biliary tract cancer (3.7%). None of the four cases associated with PBM, and the results of histological, immunohistochemical and genetic examinations differed between the bile duct and gall bladder cancers in each case.

Conclusion: Even when they do not associate with PBM, double cancers in the biliary tract are more likely to be the result of multicentric development.

Keywords: double cancer; gall bladder; bile duct; K-ras; p53.
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