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Japanese Journal of Clinical Oncology Advance Access published online on September 25, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl087
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© 2006 Foundation for Promotion of Cancer Research
Received February 13, 2006
Accepted June 15, 2006

Case Report

A Case of Resected Huge Ileocolonic Mesenteric Liposarcoma which Responded to Pre-operative Chemotherapy using Doxorubicin, Cisplatin and Ifosfamide

Seiji Ishiguro 1, Seiichiro Yamamoto 1, Hirokazu Chuman 1, and Yoshihiro Moriya 2 *

1 Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan
2 Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji Tyuo-ku, Tokyo 104-0045, Japan

* To whom correspondence should be addressed.
Yoshihiro Moriya, E-mail: sishigur{at}ncc.go.jp


  Abstract

Primary mesenteric liposarcoma is a rare entity that has been reported only 14 times in English literature. The treatment strategy for mesenteric liposarcoma is, if no distant metastases are detected, surgical resection with a wide surgical margin, often followed by radiation and/or adjuvant chemotherapy for high-risk patients. However, the efficacy of pre-operative chemotherapy is unknown. If the tumor is shrunk by pre-operative chemotherapy, we could achieve complete surgical resection, which is difficult when the tumor is too large or is invading neighboring organs. We herein describe a case of huge mesenteric liposarcoma that showed significant tumor shrinkage by pre-operative chemotherapy using doxorubicin, cisplatin and ifosfamide, allowing a margin-negative operation.

Keywords: mesenteric liposarcoma; preoperative chemotherapy; doxorubicin; ifosfamide.
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