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Japanese Journal of Clinical Oncology Advance Access published online on September 28, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl098
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© 2006 Foundation for Promotion of Cancer Research
Received April 16, 2006
Accepted August 11, 2006

Original Article

Factors Influencing the Parotid Function in Nasopharyngeal Carcinoma Treated with Parotid-Sparing Radiotherapy

Wen-Shan Liu 1 *, Steve Pai-Hsun Lee 2, Jong-Kang Lee 3, Mao-Chang Su 4, Gin-Den Chen 5, Hong-Shen Lee 6, and Huei Lee 7

1 Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine & Toxicology, Chung Shan Medical University Hospital, Taichung, Taiwan
2 Department of Radiation Oncology, University of California, Los Angeles, USA
3 Department of Nuclear Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
4 Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan
5 Institue of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
6 Institue of Public Health, Chung Shan Medical University, Taichung, Taiwan
7 Institute of Medicine & Toxicology, Chung Shan Medical University Hospital, Taichung, Taiwan

* To whom correspondence should be addressed.
Wen-Shan Liu, E-mail: p53_tw{at}yahoo.com.tw


  Abstract

Background: To evaluate the factors influencing post-irradiation parotid gland function in nasopharyngeal cancer treated with parotid-sparing radiotherapy.

Methods: This study consisted of 45 patients with nasopharyngeal cancer treated with radiotherapy including 3D conformal radiotherapy, intensity-modulated radiotherapy and high-dose-rate brachytherapy. The mean follow-up time was 37.5 months (range: 15-50 months). Objective parotid gland function was assessed by series sialoscintigraphy pre-irradiation and post-irradiation at 1, 6, 12 and 18 months. Subjective salivary function was recorded by the LENT/SOMA system. Wilcoxon signed-rank test was used to compare the secretion ratio (SR) of parotid gland before and after treatment. Mann-Whitney rank-sum test was used to determine the factors influencing the post-irradiated SR. Chi-square test was used to compare the correlation between subjective grading of xerostomia and objective grading of parotid glands.

Results: There was a significant difference between the pre-irradiation and post-irradiation parotid gland's SR at 1 (0.30 versus 0.01, P < 0.05) and 6 months (0.03 versus 0.08, P < 0.05). However, there was no significant difference compared with the pre-irradiation SR at 12 (0.30 versus 0.20, P > 0.05) and 18 months (0.30 versus 0.18, P > 0.05). There was significant correlation between subjective and objective salivary function (P = 0.024) at 12 months after radiotherapy. The factor that impacted the preservation of parotid function was mean dose to the parotid gland >38.0 Gy (P < 0.05).

Conclusions: Our results demonstrated that parotid function could recover 1 year after treatment with parotid-sparing radiotherapy in patients with nasopharyngeal cancer. The most important factor that influenced parotid function was the mean dose to the parotid gland.

Keywords: nasopharyngeal carcinoma; xerostomia; parotid-sparing radiotherapy; intensity-modulated radiotherapy; sialoscintigraphy.
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