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Japanese Journal of Clinical Oncology Advance Access published online on October 27, 2006
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl101
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© 2006 Foundation for Promotion of Cancer Research
Received December 18, 2005
Accepted July 15, 2006

Case Report

Metastatic Non-Small-Cell Lung Carcinoma Successfully Treated with Pre-operative Chemotherapy and Bilateral Adrenalectomy

Alberto Muñoz 1 *, Guillermo López-Vivanco 2, Joan-Manel Mañé 2, Ricardo Fernández 2, Javier Díaz-Aguirregoitia 3, Mónica Saiz 4, and Ramón Barceló 2

1 Department of Medical Oncology; Plaza de Cruces s/n, 48903 Barakaldo, Basque Country, Spain
2 Department of Medical Oncology
3 Department of Surgery, Unit of Endocrine Surgery
4 Department of Pathology, Hospital de Cruces, Osakidetza, Basque Country, Spain

* To whom correspondence should be addressed.
Alberto Muñoz, E-mail: amunoz{at}hcru.osakidetza.net


  Abstract

Metastatic non-small-cell lung cancer is a common condition with a dismal prognosis. Although palliative chemotherapy improves survival and quality of life, nearly all patients die of progressive disease. Metastatic involvement of adrenal glands is not rare, but usually reflects widespread dissemination. Selected patients with single adrenal metastasis may be cured with surgery, although the level of evidence comes from single cases reports and short retrospective series. Here we report a patient with bilateral adrenal metastases from previously resected non-small-cell lung cancer, who remains free of disease four years after pre-operative chemotherapy and bilateral adrenalectomy.

Keywords: non-small-cell lung carcinoma; chemotherapy; surgery; adrenalectomy.
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