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Japanese Journal of Clinical Oncology Advance Access published online on August 2, 2007
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hym079
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© 2007 Foundation for Promotion of Cancer Research

Development of Solitary Plasmacytoma in the Internal Auditory Canal and Inner Ear after Allogeneic Hematopoietic Stem Cell Transplantation for Plasma Cell Leukemia

Masatsugu Masuda1,, Yasuhiro Inoue1, Ryuji Tanosaki2, Sho Kanzaki1 and Kaoru Ogawa1

1 Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku
2 Division of Hematology and Hematopoietic Stem Cell Transplantation, National Cancer Center, Tokyo, Japan

For reprints and all correspondence: Masatsugu Masuda, Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. E-mail: masu13{at}sc.itc.keio.ac.jp

Received February 2, 2007; accepted April 27, 2007

Here we report the first case of the development of intracranial solitary plasmacytoma in the inner ear after allogeneic stem cell transplantation (allo-SCT) in a 39-year-old Japanese female with primary plasma cell leukemia (PCL). A point to note is that this is not a case on multiple myeloma but on PCL. She was successfully treated with local irradiation and survived more than 6 years from the time of diagnosis and transplantation. This case elucidates the biology of PCL and stresses the need for an individual approach to the clinical management of patients with plasma cell neoplasm undergoing allo-SCT.

Key Words: allogeneic hematopoietic stem cell transplantation • plasma cell leukemia • intracranial extramedullary plasmacytoma • MRI


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