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Japanese Journal of Clinical Oncology Advance Access published online on January 24, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyn146
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© The Author (2009). Published by Oxford University Press. All rights reserved

Metastatic Adrenocortical Carcinoma Treated with Sunitinib: A Case Report

Jeong-Ok Lee1, Keun-Wook Lee1, Chung-Jong Kim1, Yu Jung Kim1, Hee Eun Lee2, Haeryoung Kim2, Jee Hyun Kim1, Soo-Mee Bang1, Jae-Sung Kim3 and Jong Seok Lee1

1 Department of Internal Medicine
2 Department of Pathology
3 Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

For reprints and all correspondence: Keun-Wook Lee, Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeongi-do 463-707, Republic of Korea. E-mail: hmodoctor{at}hanmail.net

Received July 30, 2008; accepted November 30, 2008

Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Palliative chemotherapy can be considered in patients with metastatic disease. Although mitotane- or cisplatin-based chemotherapy regimens are widely used, the effects of these agents have been limited. We have experienced a case that showed a partial response with sunitinib after failure of mitotane-based cytotoxic chemotherapy. The clinical benefit from sunitinib persisted 7.5 months in this case. To our knowledge, this is the first reported case showing the effects of sunitinib on metastatic ACC.

Key Words: adrenocortical carcinoma • chemotherapy • sunitinib


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