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Japanese Journal of Clinical Oncology Advance Access published online on March 4, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyp005
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© The Author (2009). Published by Oxford University Press. All rights reserved

Sunitinib, a Novel Therapy for Anthracycline- and Cisplatin-refractory Malignant Pheochromocytoma

Kyung-Sun Park1, Jae-Lyun Lee1,4, Hanjong Ahn2, Jung-Min Koh1,3, Inkeun Park1, Jun-Seok Choi1, Yi Rang Kim1, Tai Sun Park1, Jin-Hee Ahn1,4, Dae Ho Lee1,4, Tae Won Kim1,4 and Jung Shin Lee1,4

1 Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center
2 Department of Urology, University of Ulsan College of Medicine, Asan Medical Center
3 Department of Endocrinology, University of Ulsan College of Medicine, Asan Medical Center
4 Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

For reprints and all correspondence: Jae-Lyun Lee, Department of Oncology and Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-2 dong, Songpa-gu, Seoul 138-736, Republic of Korea. E-mail: jaelyun{at}amc.seoul.kr

Received October 28, 2008; accepted January 12, 2009

We report a case of malignant pheochromocytoma recurred after debulking surgery. A 17-year-old male patient visited our hospital for right flank pain. He had not experienced palpitations, headache, sweating or weight loss. Level of urinary catecholamine and its metabolite increased above normal values and abdominal computed tomography showed a huge right adrenal mass. One month after debulking surgery, anterior mediastinal and multiple liver metastases were found. These tumors had no response to two conventional regimens of combination chemotherapy (cyclophosphamide, vincristine, dacarbazine and anthracycline; and etoposide and cisplatin). We treated the patient with sunitinib, a multiple tyrosine kinase inhibitor. The tumor showed very good metabolic response to the therapy. In patient with malignant pheochromocytoma, sunitinib might be one therapeutic strategy for malignant pheochromocytomas.

Key Words: malignant pheochromocytoma • sunitinib • combination chemotherapy


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