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Japanese Journal of Clinical Oncology Advance Access published online on March 24, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyp018
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© The Author (2009). Published by Oxford University Press. All rights reserved

Activity of S-1 in Advanced or Recurrent Gastric Cancer Patients after Failure of Prior Chemotherapy, Including Irinotecan + Cisplatin or Fluorouracil (Except S-1)

Akira Ono, Narikazu Boku, Yusuke Onozawa, Shuichi Hironaka, Akira Fukutomi, Hiroshi Yasui, Kentaro Yamazaki, Takayuki Yoshino, Keisei Taku and Takashi Kojima

Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan

For reprints and all correspondence: Akira Ono, Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimnagakubo, Nagaizumi, Sunto-gun, Shizuoka, Japan. E-mail: a.ono{at}scchr.jp

Received February 6, 2009; accepted February 9, 2009

We retrospectively reviewed to investigate the efficacy and toxicity of monotherapy with S-1 in patients with advanced or recurrent gastric cancer after failure of first-line chemotherapy. Twenty-one patients were evaluated. The median number of treatment cycles was 2 (range 1–19). There were no cases showing either complete or partial response, and 10 patients (47.6%) showed stable disease. The median progression-free survival was 89 days. Sixteen patients (76%) received third-line chemotherapy. The median survival time was 271 days after the initiation of S-1, with a 1-year survival rate of 32%. Hematological toxicities were Grade 4 anemia (9.5%), Grade 3 or 4 neutropenia (9.5%) and leukopenia (4.7%). As for non-hematological toxicities, Grade 3 or 4 diarrhea and anorexia were noted in 9.5% and 14.2% of the patients, respectively. S-1 was found to show no efficacy and cannot be recommended for second-line chemotherapy against gastric cancer.

Key Words: S-1 • gastric cancer • second-line


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