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Japanese Journal of Clinical Oncology Advance Access published online on March 31, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyp020
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© The Author (2009). Published by Oxford University Press. All rights reserved

Expression of the Antiapoptosis Gene Survivin Predicts Poor Prognosis of Stage III Gastric Adenocarcinoma

Kyo Young Song1, Chan Kwon Jung2, Won Sang Park3 and Cho Hyun Park1

1 Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, College of Medicine
2 Department of Hospital Pathology, The Catholic University of Korea, College of Medicine
3 Department of Pathology, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea

For reprints and all correspondence: Cho Hyun Park, Department of Surgery, Division of Gastrointestinal Surgery, The Catholic University of Korea, College of Medicine, Kangnam St Mary's Hospital, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Republic of Korea. E-mail: chaprk{at}catholic.ac.kr and skygs{at}catholic.ac.kr

Received December 12, 2008; accepted February 20, 2009

Objective: This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in Stage III gastric adenocarcinoma.

Methods: We performed immunohistochemical staining for survivin, p53 and Bax in formalin-fixed, paraffin-embedded blocks from 157 surgically resected Stage III gastric cancer tissues. To determine the association with clinical course, we reviewed the patients' clinical records.

Results: Of the 157 gastric cancer tissues, 63 (40.1%) cases showed positive expression for survivin protein. There was no significant association between survivin expression and p53 or Bax. For clinicopathologic parameters, large tumor size was closely related to survivin expression (P < 0.05). The 5-year survival rate of patients with positive survivin expression was significantly lower compared with that for survivin-negative cancer patients (P < 0.05). Survivin and p53 were independent prognostic factors in Stage III gastric cancer.

Conclusions: Survivin protein is an important predictive and prognostic parameter of poor outcome in gastric carcinoma.

Key Words: survivin • antiapoptosis • inhibitors of apoptosis proteins • prognosis • Stage III gastric cancer


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