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Japanese Journal of Clinical Oncology Advance Access published online on April 24, 2009
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyp034
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© The Author (2009). Published by Oxford University Press. All rights reserved

Relapse with Malignant Transformation After Chemotherapy for Primary Mediastinal Seminoma: Case Report

Satoru Iwasa, Masashi Ando, Makiko Ono, Taizo Hirata, Mayu Yunokawa, Eriko Nakano, Kan Yonemori, Tsutomu Kouno, Chikako Shimizu, Kenji Tamura, Noriyuki Katsumata and Yasuhiro Fujiwara

Division of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan

For reprints and all correspondence: Yasuhiro Fujiwara, Division of Breast and Medical Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. E-mail: yfujiwar{at}ncc.go.jp

Received July 29, 2008; accepted March 19, 2009

This case report details a relapse with malignant transformation after the completion of bleomycin, etoposide and cisplatin chemotherapy for primary mediastinal seminoma, although the residual mass after chemotherapy was <3 cm in size and did not display an increased uptake of fluorodeoxyglucose when examined using positron emission tomography.

Key Words: germ cell tumor • seminoma • relapse • malignant transformation • mediastinum


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